INHIBITION OF METASTATIC HEPATOCARCINOMA BY COMBINED CHEMOTHERAPY WITH SILENCING VEGF/VEGFR2 GENES THROUGH A GALNAC-MODIFIED INTEGRATED THERAPEUTIC SYSTEM

Hepatocellular carcinoma (HCC) is a highly malignant tumor related to high mortality and is still lacking a satisfactory cure.Tumor metastasis is currently a major challenge of cancer treatment, which is highly related to angiogenesis.The vascular endothelial growth factor (VEGF)/VEGFR signaling pathway is thus becoming an attractive therapeutic ta

We investigate the local exponential synchronization for complex dynamical networks with interval time-varying delays in the dynamical nodes and the switched coupling term simultaneously.The constraint on the derivative of the time-varying delay is not required which allows the time delay to be a Knife Storage fast time-varying function.By using co

In this pilot study, we investigated microvascular impairment in patients with cerebral small vessel disease (CSVD) using non-invasive arterial spin labeling (ASL) magnetic resonance imaging (MRI).This method enabled us to measure the perfusion parameters, cerebral blood flow (CBF), and arterial transit time (ATT), and the effective T1-relaxation t